LRP6 Protein Regulates Low Density Lipoprotein (LDL) Receptor-mediated LDL Uptake
نویسندگان
چکیده
منابع مشابه
A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.
OBJECTIVE A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was identified as the primary molecular defect underlying monogenic form of coronary artery disease. We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C). METHODS AND RESULTS Twelve common (minor allele frequency > or =0.1) single nucleotide polymor...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.295287